2012 Fiscal Year Final Research Report
Development of an auxiliary liver using a small intestinal segment packed together with liver microfragments and greater omentum
| Project/Area Number |
23659636
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Gunma University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Itaru 群馬大学, 生体調節研究所, 教授 (60143492)
HOSHINO Hiroo 群馬大学, 名誉教授 (00107434)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 有茎分節腸管 / 肝組織移植 / 肝細胞移植 / 補助肝臓 / 肝不全 / 肝移植 |
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| Research Abstract |
This study was conducted to improve the survival of the auxiliary liver using a small intestinal segment packed with liver microfragments by co-insertion of greater omentum. The engrafted liver microfragments were reorganized in the segmental intestine and exhibited an almost normal hepatic architecture even after the 60 or 90 days although these became completely necrotic when these were grafted without greater omentum. This method showed the possibility to develop an effective auxiliary liver.
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