2012 Fiscal Year Final Research Report
Large-scale screening system of low molecular compounds forrealization of regenerative medicine for liver diseases
| Project/Area Number |
23659650
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Tottori University |
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Principal Investigator |
SHIOTA Goshi 鳥取大学, 医学系研究科, 教授 (70263457)
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| Co-Investigator(Kenkyū-buntansha) |
HOSHIKAWA Yoshiko 鳥取大学, 医学系研究科, 助教 (10181489)
KANKI Keita 鳥取大学, 医学系研究科, 助教 (10516876)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 間葉系幹細胞 / 肝細胞分化誘導 / Wnt/beta-catenin経路 / Wnt/beta-catenin経路 / ルシフェラーゼアッセイ |
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| Research Abstract |
In order to pick up low molecular compounds which stimulate hepatic differentiate of human mesenchymal stem cells, we have developed a cell-based screening system using the #7-1-2 cells, which have TCF motif and have high luciferase activity in a dose-dependent manner, constantly and stably respond to Wnt/beta-catenin signals.
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