Establishment of therapy for individual based on diagnostic imaging by artificial virus

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659655
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kyushu University
• Principal Investigator: TANAKA Masao 九州大学, 医学研究院, 教授 (30163570)
• Co-Investigator(Kenkyū-buntansha): EGAMI Takuya 九州大学, 医学研究院, 共同研究員 (40507787) ; TAKAHATA Shunichi 九州大学, 大学病院, 助教 (50437779) ; ONIMARU Manabu 九州大学, 医学研究院, 共同研究員 (80529876)
• Project Period (FY): 2011 – 2012
• Keywords: 膵癌 / drug delivery system / 人工ウイルス

Research Abstract

We revealed HGF/c-MET pathway reduced the efficacy of virus therapy through cancer-stroma interaction. To selectively detect the specific high-grade cancer cell population, we selected CXCR4 and c-MET and created selective MRI imaging agent.

Research Products

• [Journal Article] Claudin-4 Expression Predicts Survival in Pancreatic Ductal Adenocarcinoma (2012)
  • Author(s): Tsutsumi K, Sato N, Tanabe R, Mizumoto K, Morimatsu K, Kayashima T, Fujita H, Ohuchida K, Otsuka T, Takahata S, Nakamura M, Tanaka M
  • Journal Title: Annals of Surgical oncology Volume: 19(3) Pages: 491-499
• [Journal Article] Adenoviral therapy is more effective in gemcitabine-resistant pancreatic cancer than in gemcitabine-sensitive cells (2011)
  • Author(s): Yasui T, Ohuchida K, Zhao M, Cui L, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto M, Matsumoto K, Tanaka M
  • Journal Title: Anticancer Research Volume: 31(4) Pages: 1279-1288
• [Journal Article] Tumor-stroma interactions reduce the efficacy of adenoviral therapy through the HGF-MET pathway (2011)
  • Author(s): Yasui T, Ohuchida K, Zhao M, Onimaru M, Egami T, Fujita H, Ohtsuka T, Mizumoto K, Tanaka M
  • Journal Title: Cancer science Volume: 102(2) Pages: 484-491
• [Journal Article] Inhibition of p600 expression suppresses both invasiveness and anoikis resistance of gastric cancer (2011)
  • Author(s): Sakai H, Ouchida K, Mizumoto K, Cui L, Nakata K, Toma H, Nagai E, Tanaka M
  • Journal Title: Annals of Surgical oncology Volume: 18(7) Pages: 2057-2065
• [Presentation] claudin-4発現は膵癌の予後予測因子として有用である (2011)
  • Author(s): 堤宏介、佐藤典宏、大内田研宙、大塚隆生、高畑俊一、中村雅史、水元一博、田中雅夫
  • Organizer: 第49回日本癌治療学会学術総会
  • Year and Date: 20110000