Search of organ specific tumor markers by N-glycan expression

2011 Fiscal Year Final Research Report

• Project/Area Number: 23659657
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Kagoshima University
• Principal Investigator: NATSUGOE Shoji 鹿児島大学, 医歯学総合研究科, 教授 (70237577)
• Co-Investigator(Kenkyū-buntansha): UENO Shinichi 鹿児島大学, 大学院・医歯学総合研究科, 准教授 (40322317) ; SAKODA Masahiko 鹿児島大学, 医学部・歯学部附属病院, 助教 (40418851) ; UENOSONO Yoshikazu 鹿児島大学, 大学院・医歯学総合研究科, 特任准教授 (60398279) ; UCHIKADO Yasuto 鹿児島大学, 医学部・歯学部附属病院, 助教 (30464465) ; KITA Yoshiaki 鹿児島大学, 医学部・歯学部附属病院, 助教 (30570692) ; HASHIGUCHI Teruhito 鹿児島大学, 医歯学総合研究科, 教授 (70250917)
• Project Period (FY): 2011
• Keywords: 食道癌 / 胃癌 / 大腸癌 / 膵臓癌 / N結合型糖鎖

Research Abstract

We analyzed the serum N-glycan in 37 esophageal cancer patients and 11 healthy volunteers. N-glycan expression by using OPLS method was stratified between esophageal cancer patients and healthy volunteers on the base of glycan expression pattern, We extracted six N-glycan with statistical significance between esophageal cancer patients and healthy volunteers. According to these six markers, the accuracy rate was 69. 7% to detect the esophageal cancer. These results show that six N-glycan may be a useful markers in detection of esophageal cancer.

Research Products

• [Presentation] Current Status and Future Perspective of Sentinel Node Navigation Surgery for Gastrointestinal Cancer (2011)
  • Author(s): Natsugoe S, Uenosono Y, Arigami T, Yanagita S, Haraguchi N, Kita Y, Uchikado Y, Okumura H, Matsumoto M, Ishigami S.
  • Organizer: The International Association of Surgeons, Gastroenterologists and Oncologists
  • Place of Presentation: Tokyo
  • Year and Date: 2011-11-11
• [Presentation] Clinical significance of isolated tumor cells in esophageal and gastric cancer (2011)
  • Author(s): Natsugoe S, Uenosono Y, Arigami T, Setoyama T, Yanagita S, Uchikado Y, Matsumoto M, Okumura H, Sasaki K, Kita Y, Owaki T, Ishigami S.
  • Organizer: 8^<th> International Symposium on Minimal Residual Cancer Symposium
  • Place of Presentation: Osaka
  • Year and Date: 2011-09-22
• [Presentation] Minimally invasive treatment for adenocarcinoma of esophago-gastric junction (2011)
  • Author(s): Natsugoe S, Ishigami S, Uenosono Y, Arigami T, Hagiwara T, Okumura H, , Matsumoto M, Uchikado Y, Kita Y, Owaki T, Ueno S.
  • Organizer: International Surgical Week
  • Place of Presentation: Yokohama
  • Year and Date: 2011-08-30
• [Presentation] 上部消化器癌患者の血清中N型糖鎖による新規腫瘍マーカーの可能性 (2011)
  • Author(s): 内門泰斗, 夏越祥次, 他
  • Organizer: 第66回日本消化器外科学会総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2011-07-14
• [Patent(Industrial Property Rights)] 消化器癌診断用マーカー,および消化器癌の検査方法 (2011)
  • Inventor(s): 夏越祥次
  • Industrial Property Rights Holder: 鹿児島大学
  • Industrial Property Number: 特願、2011-222353
  • Filing Date: 2011-10-06