2012 Fiscal Year Final Research Report
Proposal and verification the hypothesis "coagulation,IFNγ andPAI-1 control liver fibrosis and carcinogenesis mechanism"
| Project/Area Number |
23659660
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Digestive surgery
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
FUJIMOTO Jiro 兵庫医科大学, 医学部, 教授 (90199373)
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| Co-Investigator(Kenkyū-buntansha) |
IIMURO Yuji 兵庫医科大学, 医学部, 教授 (30252018)
HIRANO Tadamichi 兵庫医科大学, 医学部, 講師 (90340968)
UYAMA Naoki 兵庫医科大学, 医学部, 研究生(研究員) (70402873)
NAKANISHI Kenji 兵庫医科大学, 医学部, 教授 (60172350)
NISHIGUCHI Syuhei 兵庫医科大学, 医学部, 教授 (10192246)
YOSHIMOTO Tomohiro 兵庫医科大学, 医学部, 教授 (60241171)
KONDO Yuichi 兵庫医科大学, 医学部, 助教 (70567213)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 肝線維化 / IFN-γ / PAI-1 / tPA |
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| Research Abstract |
We elucidated that blood coagulation system and IFN-γ(Interferon-gamma), PAI-1(Plasminogen activator inhibitor-1) controlled the adhesion, desmoplasia by operation adhesion mechanism analysis. From this analysis, we hypothesized that blood coagulation system, IFN-γ, PAI-1 played an important role in liver fibrosis and inspected it by the PAI-1 knockout mice, and it was suggested that PAI-1 and t-PA （tissue plasminogen activator) affected liver fibrosis but IFN-γ did not contribute so much using a mouse model that was ligated bile duct.
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