2012 Fiscal Year Final Research Report
Engineering a bioartificial heart by using extracellular matrix scaffold
| Project/Area Number |
23659672
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Thoracic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
SANO Shunji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50235438)
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| Co-Investigator(Renkei-kenkyūsha) |
王 英正 岡山大学, 岡山大学病院, 教授 (50372579)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細胞外マトリックス / 心臓内幹細胞 / 潅流培養 |
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| Research Abstract |
The shortage of donors for heart transplantation has become a critical issue to treat the patients with end-stage of cardiac failure. We have decellularized the rat whole heart by using pulsatile perfusion apparatus. Human cardiac progenitor cells were mixed with endothelial progenitor cells inculture and those were perfused to recellularize the acellular construct. Following 8 days in continuous perfusion, reseeded cells were engrafted onto the matrixto reconstruct the entire vascular beds and myocardium ex vivo.
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[Journal Article] Outcomes of one-lung fontan operation: a retrospective multicenter study in Japan2012
Author(s)
Fujii Y, Sano S, Asou T, Imoto Y, Oshima Y, Kawasaki S, Kishimoto H, Sakamoto K, Maeda M, Yamagishi M, Matsuo K.
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Journal Title
Annals of Thoracic Surgery
Volume: 94(4)
Pages: 1275-80
Peer Reviewed
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[Journal Article] Sugimachi M Medetomidine, an α2-adrenergic agonist, activates cardiac vagal nerve through modulation of baroreflex control.2012
Author(s)
Shimizu S, Akiyama T, Kawada T,Sata Y, Mizuno M, Kamiya A, Shishido T, Inagaki M, Shirai M, Sano S
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Journal Title
Circulation Journal
Volume: 76(1)
Pages: 152-9
Peer Reviewed
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