Challenges to identify endogenous factors associating with cardiac regeneration in heart failure.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659673
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Thoracic surgery
• Research Institution: Yamaguchi University
• Principal Investigator: HAMANO Kimikazu 山口大学, 大学院・医学系研究科, 教授 (60263787)
• Co-Investigator(Kenkyū-buntansha): LI Tao-sheng 長崎大学, 大学院・医歯薬総合研究科, 教授 (50379997) ; MIKAMO Akihito 山口大学, 大学院・医学系研究科, 准教授 (30372709)
• Project Period (FY): 2011 – 2012
• Keywords: 心不全 / 心筋再生 / 補助心臓 / メカニカルストレス

Research Abstract

In clinical scenes, patients with severe heart failure show poor prognosis in spite of the capacity. Here, we investigate to identify factors associating with self-regeneration of adult heart using an assist heart mouse model. The left anterior descending coronary artery was ligated to make an acute myocardial infarction in mouse heart (C57BL/6), and then infarcted heart was transplanted into abdomen of recipient mouse. In this model, weight of ventricle was significantly increased and showed longer retention of transplanted cells in unloading group. Our results demonstrate effects of cardiac mechanical stress on not only self-regeneration capacity but also efficacy of cell transplantation into heart and are useful to establish novel therapeutic approach for cardiac regeneration.

Research Products

• [Journal Article] The effects of mechanical stress on the growth, differentiation, and paracrine factor production of cardiac stem cells (2011)
  • Author(s): Kurazumi H, Kubo M, Ohshima M, Yamamoto Y, Takemoto Y, Suzuki R, Ikenaga S, Mikamo A, Udo K, Hamano K, Li TS
  • Journal Title: PLoS One Volume: 6(12) Pages: e28890
  • Peer Reviewed
• [Presentation] メカニカルストレスが細胞移植による心筋再生療法に対して及ぼす影響 (2012)
  • Author(s): 蔵澄宏之、李桃生、山本由美、西本新、久保正幸、濱野公一
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜 パシフィコ横浜
  • Year and Date: 2012-06-12
• [Presentation] 心臓が発生するメカニカルストレスに着目した心筋再生療法に関する研究 (2012)
  • Author(s): 蔵澄宏之、李桃生、池永茂、白澤文吾、美甘章仁、濱野公一
  • Organizer: 第11回再生心臓血管外科治療研究会
  • Place of Presentation: 秋田 秋田キャッスルホテル
  • Year and Date: 2012-04-11
• [Presentation] Mechanical stress suppresses the proliferation and improves the differentiation of cardiac stem cells and increases the release of paracrine factors (2012)
  • Author(s): Kurazumi H, Li TS, Kubo M, Ikenaga S, Mikamo A, Hamano K
  • Organizer: ASCVTS 20th annual meeting
  • Place of Presentation: Bari, Indonesia
  • Year and Date: 2012-03-07
• [Presentation] メカニカルストレスが心筋幹細胞へ及ぼす影響 (2011)
  • Author(s): 蔵澄宏之、李桃生、池田聡、大島真子、工藤智明、竹本圭宏、鈴木亮、久保正幸、池永茂、白澤文吾、美甘章仁、濱野公一
  • Organizer: 第64回日本胸部外科学会総会
  • Place of Presentation: 名古屋 名古屋国際会議場
  • Year and Date: 2011-10-09