2013 Fiscal Year Final Research Report
An attempt to pioneer a new research field through fusion of studies on cancer cell energy metabolism and glioma stem cells
| Project/Area Number |
23659682
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yamagata University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUNAYAMA Jun 山形大学, 医学部, 助教 (80466606)
SATO Atsushi 山形大学, 医学部, 助教 (30455901)
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| Project Period (FY) |
2011 – 2012
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| Keywords | glioma-initiating cell |
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| Research Abstract |
In this project, we investigated the effect of a mitochondrial respiration-promoting agent on glioma stem cells with the intention to test the working hypothesis that inhibited mitochondrial respiration accompanied by increased aerobic glycolysis (Warburg effect), which has been frequently observed in malignant gliomas, contributes to the maintenance of glioma stem cells. Our results showed that promotion of mitochondrial respiration caused loss of stemness of glioma stem cells, suggesting that Warburg effect plays a significant role in the maintenance of glioma stem cells and that Warburg effect may be a promising target for cancer stem cell-directed therapy.
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[Journal Article] JNK contributes to temozolomide resistance of stem-like glioblastoma cells via regulation of MGMT expression2014
Author(s)
Okada M, Sato A, Shibuya K, Watanabe E, Seino S, Suzuki S, Seino M, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Int J Oncol
Volume: 44
Pages: 591-599
Peer Reviewed
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[Journal Article] Glioma-initiating cell elimination by metformin activation of FOXO3 via AMPK2012
Author(s)
Sato A, Sunayama J, Okada M, Watanabe E, Seino S, Shibuya K, Suzuki K, Narita Y, Shibui S, Kayama T,Kitanaka C
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Journal Title
Stem Cells Transl Med
Volume: 1
Pages: 811-824
Peer Reviewed
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[Journal Article] Targeting JNK for therapeutic depletion of stem-like glioblastoma cells2012
Author(s)
Matsuda K, Sato A, Okada M, Shibuya K, Seino S, Suzuki K, Watanabe E, Narita Y, Shibui S, Kayama T, Kitanaka C
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Journal Title
Sci Rep
Volume: 2
Pages: 516
Peer Reviewed
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[Journal Article] FoxO3a functions as a key integrator of cellular signals that control glioblastoma stem-like cell differentiation and tumorigenicity2011
Author(s)
Sunayama J, Sato A, Matsuda KI, Tachibana K, Watanabe E, Seino S, Suzuki K, Narita Y, Shibui S, Sakurada K, Kayama T, Tomiyama A, Kitanaka C
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Journal Title
Stem Cells
Volume: 29
Pages: 1327-1337
Peer Reviewed
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[Presentation] グリオーマ幹細胞におけるFoxO3a を介した分化と造腫瘍能の制御2011
Author(s)
佐藤篤, 砂山潤, 松田憲一朗, 立花研, 渡部江梨子, 清野静香, 鈴木香,成田善孝, 渋井壮一郎, 富山新太, 北中千史, 嘉山孝正
Organizer
第29回日本脳腫瘍学会学術総会
Place of Presentation
下呂
Year and Date
2011-11-27
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