2013 Fiscal Year Final Research Report
Novel molecular target for cerebrovascular disease: CYR61 as angiogenic inducer
| Project/Area Number |
23659686
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Okayama University |
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Principal Investigator |
DATE Isao 岡山大学, 医歯(薬)学総合研究科, 教授 (70236785)
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| Co-Investigator(Kenkyū-buntansha) |
KUROZUMI Kazuhiko 岡山大学, 岡山大学病院, 講師 (20509608)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIU Kenji 岡山大学, 岡山大学病院, 准教授 (40325105)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 脳血管障害学 / CCNファミリー |
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| Research Abstract |
We study the expression levels of the secreted protein cysteine-rich angiogenic-inducer 16 (CYR61) in patients with cerebrovascular disease and aim to develop a therapeutic strategy for CYR61. We received a CYR61-expressing plasmid from collaborators and identified an effective shRNA against CYR61. In brain tumor patients, multivariate Cox analysis revealed that CYR61 was an independent prognostic factor of survival. Now, we are evaluating the expression levels of CYR61 in different models of cerebrovascular disease.
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[Presentation] Induction of an angiogenec factor, CYR61, in oncolytic viral therapy for malignant gliomas2013
Author(s)
Kurozumi K, Ichikawa T, Fujii K, Shimazu Y, Onishi M, Ishida J, Chiocca EA, Kaur B, Date I
Organizer
第19回日本遺伝子治療学会年次学術集会(The 19th Annual Meeting of Japan Society of Gene Therapy)
Place of Presentation
岡山
Year and Date
2013-07-05
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