2012 Fiscal Year Final Research Report
Identification of a novel biomarker of brain tumor based on the analysis of exosomal microRNA
| Project/Area Number |
23659691
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIMOTO Koji 九州大学, 大学病院, 講師 (70444784)
NAKAMIZO Akira 九州大学, 医学(系)研究科(研究院), 講師 (80529800)
AMANO Toshiyuki 九州大学, 大学病院, 助教 (70448413)
HATA Nobuhiro 九州大学, 大学病院, 助教 (10596034)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳腫瘍 / 神経膠腫 / microRNA / エキソソーム |
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| Research Abstract |
We isolated exosomal microRNAs from culture medium of glioma cell and total serum of glioma patients. The expression of secreted microRNA in the culture medium is correlated the microRNA expression of cultured glioma cells. We also established brain tumor stem cells and mouse xenograht models. We successfully analyzed secreted microRNA expression in total serum of xenographt models. We compared microRNA expression and gene expression in primary glioma samples, and revealed that miR-128a and miR-504 are associated with mesenchymal gene expression.
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[Journal Article] Associations between microRNA expression and mesenchymal marker gene expression in glioblastoma2012
Author(s)
Ma X, Yoshimoto K, Guan Y, Hata N,Mizoguchi M, Sagata N, Murata H, Kuga D, Amano T, Nakamizo A, Sasaki T
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Journal Title
Neuro Oncol
Volume: 14(9)
Pages: 1153-62
DOI
Peer Reviewed
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