2012 Fiscal Year Final Research Report
Analysis of signal transduction pathways in brain pericytes in ischemic stroke
| Project/Area Number |
23659692
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Kyushu University |
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Principal Investigator |
SASAKI Tomio 九州大学, 医学研究院, 教授 (10134561)
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| Co-Investigator(Kenkyū-buntansha) |
MIZOGUCHI Masahiro 九州大学, 大学病院, 講師 (50380621)
NAKAMIZO Akira 九州大学, 医学研究院, 講師 (80529800)
KIKKAWA Yuichiro 九州大学, 大学病院, 助教 (80423515)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 脳血管障害 / 周皮細胞 / 細胞内シグナル |
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| Research Abstract |
It has been suggested recently that brain pericytes play various important roles in ischemic stroke, but its detail mechnism remains elusive. In our project, we demonstrated that PDGFRβsignaling in brain pericytes in peri-infarct area was enhanced by basic fibroblast growth factor(bFGF) and mediated cell growth, survival and production of neurotrophic factors.
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