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2012 Fiscal Year Final Research Report

Aberrant pre-mRNA splicing that contributes to increased glycolysis in glioma

Research Project

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Project/Area Number 23659700
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Cerebral neurosurgery
Research InstitutionMiyagi Cancer Center Research Institute

Principal Investigator

KATAKURA Ryuuichi  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (10442675)

Co-Investigator(Kenkyū-buntansha) ITO Sigemi  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
TANUMA Nobuhiro  地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
Project Period (FY) 2011 – 2012
Keywords代謝 / 解糖系 / ワールブルグ効果 / PKM / グリオーマ
Research Abstract

Pre-mRNA splicing of gene encoding pyruvate kinase M (PKM), a glycolytic enzyme, was dys-regulated, so that expression of PKM isoforms switches from normal- to tumor-type in human glioma. This aberrant splicing was associated with increased levels of a splicing modulator. Experiments using cell-lines showed that suppression of the splicing regulator results in partial restoration of expression of a normal-type PKM isoform. Additionally, we developed mice model in which the isozyme-conversion of PKM is disabled.

  • Research Products

    (8 results)

All 2013 2012 2011

All Journal Article (4 results) Presentation (4 results)

  • [Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012

    • Author(s)
      Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
    • Journal Title

      Oncol Rep.

      Volume: 28(3) Pages: 931-6

    • DOI

      doi:10.3892/

  • [Journal Article] Case report of Mammary Analog Secretory Carcinoma of the parotid gland2012

    • Author(s)
      Ito S, Ishida E, Skalova A, Matsuura K, Kumamoto H, Sato I
    • Journal Title

      Pathol Int.

      Volume: 62(2) Pages: 149-52

    • DOI

      doi:10.1111/j.1440-1827.2011.02759.x.

  • [Journal Article] 発がんにおけるPKMスイッチ-意義と分子機構2012

    • Author(s)
      田沼延公
    • Journal Title

      実験医学 特集「がんと代謝」

      Volume: Vol. 30、No. 15 Pages: 42-47

  • [Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011

    • Author(s)
      Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
    • Journal Title

      Mol Cell Biochem.

      Volume: 352(1-2) Pages: 155-62

    • DOI

      doi:10.1007/s11010-011-0749-x.

  • [Presentation] PKMスイッチ不可能なマウスモデルの開発2013

    • Author(s)
      田沼延公
    • Organizer
      日本癌学会 がん代謝シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2013-01-17
  • [Presentation] 炎症性脳アミロイド血管症の一例2012

    • Author(s)
      山下洋二、鈴木博義、伊藤しげみ、佐藤郁郎、片倉隆一
    • Organizer
      第19回東北脳神経病理研究会
    • Place of Presentation
      福島
    • Year and Date
      2012-11-17
  • [Presentation] 悪性グリオーマ検体およびグリオーマ樹立株におけるPTPzetaの解析2012

    • Author(s)
      山下洋二、春日井勲、田沼延公、柴原一陽、園田順彦、金森政之、齋藤竜太、隈部俊宏、冨永悌二、島礼、片倉隆一
    • Organizer
      日本脳神経外科学会 第71回総会
    • Place of Presentation
      大阪
    • Year and Date
      2012-10-18
  • [Presentation] A mouse model incapable of switching PKM isoforms2012

    • Author(s)
      田沼延公、渡邊利雄、野村美有樹、佐藤郁郎、椎葉健一、山下洋二、佐藤雅美、島礼
    • Organizer
      第71回日本癌学会学術総会
    • Place of Presentation
      札幌
    • Year and Date
      2012-09-20

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Published: 2014-09-25  

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