2012 Fiscal Year Final Research Report
Aberrant pre-mRNA splicing that contributes to increased glycolysis in glioma
| Project/Area Number |
23659700
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Miyagi Cancer Center Research Institute |
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Principal Investigator |
KATAKURA Ryuuichi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (10442675)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Sigemi 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 特任研究員 (80600006)
TANUMA Nobuhiro 地方独立行政法人宮城県立病院機構宮城県立がんセンター(研究所), がん薬物療法研究部, 主任研究員 (40333645)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 代謝 / 解糖系 / ワールブルグ効果 / PKM / グリオーマ |
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| Research Abstract |
Pre-mRNA splicing of gene encoding pyruvate kinase M (PKM), a glycolytic enzyme, was dys-regulated, so that expression of PKM isoforms switches from normal- to tumor-type in human glioma. This aberrant splicing was associated with increased levels of a splicing modulator. Experiments using cell-lines showed that suppression of the splicing regulator results in partial restoration of expression of a normal-type PKM isoform. Additionally, we developed mice model in which the isozyme-conversion of PKM is disabled.
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Research Products
(8 results)
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[Journal Article] Novel function of MKP-5/DUSP10, a phosphatase of stress-activated kinases, on ERK-dependent gene expression, and upregulation of its gene expression in colon carcinomas2012
Author(s)
Nomura M, Shiiba K, Katagiri C, Kasugai I, Masuda K, Sato I, Sato M, Kakugawa Y, Nomura E, Hayashi K, Nakamura Y, Nagata T, Otsuka T, Katakura R, Yamashita Y, Sato M, Tanuma N, Shima H
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Journal Title
Oncol Rep.
Volume: 28(3)
Pages: 931-6
DOI
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[Journal Article] DUSP13B/TMDP inhibits stress-activated MAPKs and suppresses AP-1-dependent gene expression2011
Author(s)
Katagiri C, Masuda K, Nomura M, Tanoue K, Fujita S, Yamashita Y, Katakura R, Shiiba K, Nomura E, Sato M, Tanuma N, Shima H
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Journal Title
Mol Cell Biochem.
Volume: 352(1-2)
Pages: 155-62
DOI
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