2012 Fiscal Year Final Research Report
Establishment and application of in-vitro hypertrophic and degeneration model designed to clarify the mechanism of mechanical signal transduction in chondrocytes.
| Project/Area Number |
23659705
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MATSUBARA Takehiro 東京大学, 医学部附属病院, 助教 (40361498)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨 / 軟骨代謝学 |
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| Research Abstract |
The purpose of this study is to establish in-vitro hypertrophic and degeneration model designed to clarify the mechanism of mechanical signal transduction in chondrocytes. The examination of expressions of degeneration markers of chondrocytes under various conditions of hydrostatic pressure revealed that pressure of 20MPa for 1 hour was the optimum stimulus condition to induce degenerative change in mouse chondrogenic ATDC5 cells and mouse primary articular chondrocytes.
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