2012 Fiscal Year Final Research Report
A study on the transcriptional regulation of type II collagen and aggrecan
| Project/Area Number |
23659713
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
SHINOMURA Tamayuki 東京医科歯科大学, 大学院・医歯学総合研究科, 准教授 (70206118)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 軟骨 / コラーゲン / アグリカン / エンハンサー / 転写制御 |
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| Research Abstract |
Type II collagen and aggrecan which are the major components of cartilage occupy more than 50% of the tissue dry weight. In this study, the transcriptional mechanism that controls the high level expression of these two molecules in chondrocytes was analyzed. As a result, I found new enhancer elements that areresponsible for the regulation of each gene expression.
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