Elucidation of the role of reactive oxygen species in bone metabolism

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659714
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: MORITA Sadao 東京医科歯科大学, 医歯学総合研究科, 准教授 (20202426)
• Co-Investigator(Kenkyū-buntansha): ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (50345279)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Shu 慶應義塾大学, 医学部, 特任准教授 (30376727)
• Project Period (FY): 2011 – 2012
• Keywords: 骨代謝 / 酸化ストレス / 活性酸素 / シグナル伝達機構 / 破骨細胞

Research Abstract

We aimed to study the role of reactive oxygen species in bone metabolism by using osteoclast-specific PHGPX-deficient mice. These mice developed hypoplasia of auricle, increase in osteoclast differentiation.

Research Products

• [Journal Article] Comparison of different distal designs of femoral components and their effects on bone remodeling in 1-stage bilateral total hip arthroplasty (2012)
  • Author(s): Yamauchi Yuki, Jinno Tetsuya, Koga Daisuke, Asou Yoshinori, Morita Sadao, Okawa Atsushi
  • Journal Title: J Arthroplasty Volume: 27巻 Pages: 1538-43
  • Peer Reviewed
• [Journal Article] The Effect of Mastication on Reaction Latency to UnanticipatedExternal Disturbances in the Standing Position (2012)
  • Author(s): Keisuke Kaji, Munenori Katoh, Koji Isozaki, Junya Aizawa, Tadashi Masuda, Sadao Morita
  • Journal Title: Journal of Medical and Dental Sciences Volume: 59巻 Pages: 83-88
  • Peer Reviewed
• [Journal Article] THA前後における中殿筋と大殿筋の筋断面性の回復とJOA Hip Score との関連-CTを用いて (2012)
  • Author(s): 勝木員子,相澤純也、磯崎弘司、神野哲也、森田定雄
  • Journal Title: 理学療法学 Volume: 39巻 Pages: 122-23
  • Peer Reviewed
• [Journal Article] 両側一期的人工股関節全置換術におけるドレーン留置の有用性に関する検討 (2012)
  • Author(s): 小谷野岳,神野哲也,麻生義則,古賀大介,谷口直史,高田ちさと,宗田大,大川淳,森田定雄,山内裕樹
  • Journal Title: Hip Joint Volume: 38巻 Pages: 472-475
  • Peer Reviewed
• [Journal Article] 人工股関節全置換術における関節安定性前方アプローチと後側方アプローチの術中比較 (2012)
  • Author(s): 古賀大介,神野哲也,宗田大,森田定雄
  • Journal Title: 日本関節病学会誌 Volume: 31巻 Pages: 7-11
  • Peer Reviewed
• [Journal Article] 人工股関節全置換術における神経麻痺発生の危険因子の検討 (2012)
  • Author(s): 高田ちさと,古賀大介,神野哲也,麻生義則,山内裕樹,谷口直史,小谷野岳,佐々木亨,森田定雄,宗田大,大川淳
  • Journal Title: Hip Joint Volume: 38巻 Pages: 448-452
  • Peer Reviewed