Clarification of the crosstalk between bone and blood pressure control.

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659715
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Orthopaedic surgery
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: OKAWA Athushi 東京医科歯科大学, 医歯学総合研究科, 教授 (30251507)
• Co-Investigator(Kenkyū-buntansha): ASO Yoshinori 東京医科歯科大学, 医歯学総合研究科, 寄付講座教員 (50345279)
• Co-Investigator(Renkei-kenkyūsha): TAKEDA Shu 慶應義塾大学, 医学部, 特任准教授 (30376727)
• Project Period (FY): 2011 – 2012
• Keywords: 骨代謝 / 血圧調節機構 / プロレニン受容体 / 破骨細胞 / 骨芽細胞 / 軟骨細胞

Research Abstract

To address the role of Prorenin Receptor(PRR) in bone metabolism, bone-specific PRR-deficient mice were analyzed. These mice displayed significantly reduced bone mass, inhibition of bone formation and decrease in the expression of osteoblast markers.

Research Products

• [Journal Article] Porous/Dense composite hydroxyapatite for anterior cervical discectomy and fusion (2013)
  • Author(s): Yoshii T, Yuasa M, Sotome S, Yamada T, Sakaki K, Hirai T, Taniyama T, Inose H, Kato T, Arai Y, Kawabata S, Tomizawa S, Enomoto M, Shinomiya K, Okawa A
  • Journal Title: Spine Volume: 38(10) Pages: 833-40
  • DOI: Doi:10.1097/BRS.0b013e3182801390
  • Peer Reviewed
• [Journal Article] ModifiedK-line in magnetic resonanceimaging predicts insufficient decompression of cervical laminoplasty (2013)
  • Author(s): Taniyama T, Hirai T, Yamada T, Yuasa M, Enomoto M, Yoshii T, Kato T, Kawabata S, Inose H, Okawa A
  • Journal Title: Spine Volume: 38(6) Pages: 496-501
  • DOI: Doi:10.1097/BRS.0b013e318273a4f7
  • Peer Reviewed
• [Journal Article] Dural closure for the treatment of superficial siderosis (2013)
  • Author(s): Egawa S, Yoshii T, Sakaki K, Inose H, Kato T, Kawabata S, Tomizawa S, Okawa A
  • Journal Title: Journal of Neurosurgery: Spine Volume: 18(4) Pages: 388-93
  • DOI: Doi:10.3171/2013.1.SPINE12649
  • Peer Reviewed
• [Journal Article] Lymphadenectomy and histologic subtype affect overall survival of soft tissue sarcoma patients with nodal metastases (2013)
  • Author(s): Sawamura C, Matsumoto S, Shimoji T, Ae K, Okawa A
  • Journal Title: Clin Orthop Relat Res Volume: 471(3) Pages: 926-31
  • DOI: Doi:10.1007/s11999-012-2568-0
  • Peer Reviewed
• [Journal Article] Vertebral locking lesion following cervical spinefracture in ankylosing spondylitis (2012)
  • Author(s): Kuroiwa T, Yoshii T, Sakaki K, Inose H, Tomizawa S, Kato T, Kawabata S, Shinomiya K, Okawa A
  • Journal Title: Orthopedics Volume: 35(6) Pages: e1005-8
  • DOI: Doi:10.3928/01477447-20120525-54
  • Peer Reviewed
• [Journal Article] Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice (2012)
  • Author(s): Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, Hirai Y, Sotome S, Mizusawa H, Shinomiya K, Okawa A, Yokota T
  • Journal Title: Hum Gene Ther Methods Volume: 23(2) Pages: 119-27
  • Peer Reviewed
• [Journal Article] Spinal epidural abscess caused by bacteroides fragilis group afterdilation and curettage for incomplete abortion (2012)
  • Author(s): Ohyagi M, Ohkubo T, Taniyama T, Tomizawa S, Okawa A, Yokota T, Mizusawa H
  • Journal Title: J Glob Infect Dis Volume: 4(2) Pages: 132-4
  • Peer Reviewed
• [Journal Article] Increase in paravertebral muscle activityin lumbar kyphosis patients by surface electromyography compared with lumbar spinal canal stenosis patients and healthy volunteers (2012)
  • Author(s): Enomoto M, Ukegawa D, Sakaki K, Tomizawa S, Arai Y, Kawabata S, Kato T, Yoshii T, Shinomiya K, Okawa A
  • Journal Title: J Spinal Disord Tech Volume: 25(6) Pages: E167-73
  • Peer Reviewed
• [Journal Article] Subcutaneous injections of platelet-rich plasma into skin flaps modulate proangiogenic gene expression and improve survival rates (2012)
  • Author(s): Li W, Enomoto M, Ukegawa M, Hirai T, Sotome S, Wakabayashi Y, Shinomiya K, Okawa A
  • Journal Title: Plast Reconstr Surg Volume: 129(4) Pages: 858-66
  • Peer Reviewed
• [Journal Article] Conductive neuromagnetic fields in the lumbar spinal canal (2012)
  • Author(s): Ishii S, Kawabata S, Tomizawa S, Tomori M, Sakaki K, Shinomiya K,Sekihara K, Sato T, Adachi Y, Okawa A
  • Journal Title: Clin Neurophysiol Volume: 123(8) Pages: 1656-61
  • Peer Reviewed