2012 Fiscal Year Final Research Report
Establishment of genetically modified mice for the analysis of tendon/ligament formation and regeneration
| Project/Area Number |
23659718
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto University |
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Principal Investigator |
SHUKUNAMI Chisa 京都大学, 再生医科学研究所, 准教授 (60303905)
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| Research Collaborator |
SUGIMOTO Yuki 京都大学, 再生医科学研究所, 研究生
SHIMAMURA Satoko 京都大学, 再生医科学研究所, 大学院・生
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| Project Period (FY) |
2011 – 2012
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| Keywords | Scleraxis / Tenomodulin / 腱 / 靱帯 / 運動器 |
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| Research Abstract |
During mouse development, Scleraxis(Scx), a basic-helix-loop-helix transcription factor, is continuously expressed in the tendon/ligament cell lineage, but transiently expressed in chondroprogenitors near the prospective attachment sites of tendons/ligaments into the skeletal elements. Tenomodlin(Tnmd), a type II transmembrane glycoprotein, is expressed in mature tenocytes and ligamentocytes. In this study, we have successfully generated genetically modified mice expressing Cre-recombinaseor fluorescent reporter genes in the expression domains of Scxor Tnmdas valuable tools for the analysis of tendon/ligament formation and regeneration
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