2013 Fiscal Year Final Research Report
Regeneration of growth plate using mesenchymal stem cells
| Project/Area Number |
23659721
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Osaka University |
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Principal Investigator |
YOSHIKAWA Hideki 大阪大学, 医学(系)研究科(研究院), 教授 (60191558)
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| Co-Investigator(Kenkyū-buntansha) |
HIGUCHI Chikahisa 大阪大学, 保健センター, 助教 (40432421)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 成長軟骨帯損傷 / 骨橋 / 間葉系細胞 / 3次元人工組織 / 変形矯正 |
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| Research Abstract |
Growth plate injuries often cause bone shortening or angular deformities of affected bones because of total or partial bony bridging between epiphysis and metaphysis. In order to explore new method of the treatment of growth plate injuries, we investigated availability of 3-dimentional artificial tissue, which is made of synovium-derived mesenchymal stem cells, for the regeneration of injured growth plate. Our results demonstrated that physis-like cartilage tissue was reorganized by implantation of 3D tissue. Moreover, we confirmed that correction of bone shortening or angular deformities was followed after the regeneration of tissue regeneration.
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Research Products
(8 results)
