2012 Fiscal Year Final Research Report
Identifidcation of Runx2 arginine methylation as a potent of target for osteosarcoma
| Project/Area Number |
23659724
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Okayama University |
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Principal Investigator |
OZAKI Toshifumi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40294459)
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| Research Collaborator |
KAWAI Akira 独立行政法人国立がん研究センター, 中央病院, 医長
ITO Tatsuo Memorial Sloan-Kettering Cancer Center, Molecular pathology, researcher
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| Project Period (FY) |
2011 – 2012
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| Keywords | RUNX2 / PRMTs / 蛋白修飾 / バイオマーカー |
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| Research Abstract |
We examined the interaction between PRMT4 and 5 with RUNX2, is major transcription factor in osteoblast differentiation. We found the post-translational arginine methylation of. Using aRunx2me2 antibody we also disclosed the frequency of Runx2me2s is high at Japanese OS patient of poor prognosis in long term prognosis (p
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