2012 Fiscal Year Final Research Report
Challenging study of immunotherapy for osteosarcoma usingmicroparticles induced by photodynamic therapy
| Project/Area Number |
23659730
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Heian Jogakuin(St.Agnes')University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ASHIHARA Eishi 京都府立医科大学, 医学(系)研究科, 講師 (70275197)
HOSOGI Shigekuni 京都府立医科大学, 医学(系)研究科, 講師 (30433254)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨肉腫 / アクリジンオレンジ / 光線力学的治療法 / 微粒子 / エキソゾーム / 免疫療法 / マクロファージ |
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| Research Abstract |
In this study, we undertook to investigate inhibition effect oftumor growth and pulmonary metastasis on mouse osteosarcoma by immurlotherapy withmicroparticles induced by photodynamic therapy with acridine orange. Results showed thatthese microparticles including exQsomes did rlot inhibit tumor growth and pulmonarymetastasis, because they did not activate immunoactivity via macrophages
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Research Products
(28 results)
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[Journal Article] Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts.2013
Author(s)
Aoi W,Hosogi S, Niisato N, Yokoyama N, Hayata H, Miyazaki H, Kusuzaki K, Fukuda T, Fukui M, Nakamura N, Marunaka Y
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Journal Title
BBRC
Volume: 432
Pages: 650-653
Peer Reviewed
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[Journal Article] Trarlslationalresearch of photodynamic therapy with acridine orange which targets cancer acidity.2012
Author(s)
Kusuzaki K, Ashihara E, Hosogi S, Matsubara T, Satonaka H, Nanamura T, Matsumine A, Murata H, Sudo A, Uchida A, Murata H, Baldini N, Fais S, Marunaka Y.
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Journal Title
Current Pharmaceutical Design
Volume: 18
Pages: 1414-11420
Peer Reviewed
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[Journal Article] Acridine orange inhibits pulmonary metastasis of mouse steosarcoma.2011
Author(s)
Satonaka H, Kusuzaki K, Akeda K, Tsujii M, Iino T, Uemura T, Matsubara T,Nakamura T, Asanuma K, Matsumine T, Sudo A
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Journal Title
Anticancer Res
Volume: 31
Pages: 4163-4168
Peer Reviewed
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