2012 Fiscal Year Final Research Report
Possibility of connexin43 as a new therapeutic target for rheumatoid arthritis
| Project/Area Number |
23659731
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TERAUCHI Ryu 京都府立医科大学, 医学研究科, 助教 (20575154)
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| Co-Investigator(Kenkyū-buntansha) |
ARAI Yuji 京都府立医科大学, 医学研究科, 講師 (50347449)
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| Project Period (FY) |
2011 – 2012
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| Keywords | リウマチ病学 |
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| Research Abstract |
The objective of the present study was to determine whether the expression of connexin 43 (Cx43) effected on inflammatory conditions in rat fibroblast-like synoviocytes (FLS) and on rat model of rheumatoid arthritis (RA). Treatment of CIA rats with siCx43 significantly ameliorated paw swelling, and significantly reduced histological arthritis scores and radiographic scores. In histological appearance of rat ankle joints, siCx43 treatment significantly decreased the number of tartrate-resistant acid phosphatase (TRAP)-positive (osteoclast-like) cells. These findings indicated that siCx43 had anti-inflammatory effects in rat FLS and efficiently inhibited the development of CIA. Cx43 may play an important role in the pathophysiology of RA, and may be a potential target molecule for novel RA therapies.
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