2011 Fiscal Year Final Research Report
A novel model for connecting growth and differentiation
| Project/Area Number |
23659732
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Saitama Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHTE Satoshi 埼玉医科大学, 医学部, 助教 (00547979)
SASANUMA Hiroki 埼玉医科大学, 医学部, 研究員 (30571707)
YONEYAMA Katsumi 埼玉医科大学, 医学部, 助手 (20571574)
SHIN Masashi 埼玉医科大学, 医学部, 研究員 (70549261)
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| Project Period (FY) |
2011
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| Keywords | 遺伝子 / 転写 / 細胞・組織 / 骨形成 |
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| Research Abstract |
We analyzed Bone morphogenetic protein(BMP)-responsive element(BRE) in the Id2 and Id3 genes. They had homologous BREs containing a 6 bp core sequence. The core sequence was essential for both the BMP-response and recognition by Smads. Co-transfection of Smad1 and Smad4 induced the reporter activity. These findings suggest that BMP signaling induces transcription of the Id genes through binding of Smads to the core sequences in the BREs.
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[Journal Article] Accumulation of p100, a precursor of NF-・B2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice2012
Author(s)
Seo Y, Fukushima H, Maruyama T, Kurikoshi K, Osawa K, Nagano K, Aoki K, Weih F, Doi T, Zhang M, Ohya K, Katagiri T, Hosokawa R, and Jimi E.
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Journal Title
Mol Endocrinol
Volume: 26
Pages: 414-422
Peer Reviewed
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[Journal Article] Identification and functional analysis of Zranb2 as a novel Smad-binding protein that suppresses BMP signaling2011
Author(s)
Ohte S, Kokabu S, Iemura S, Sasanuma H, Yoneyama K, Shin M, Suzuki S, Fukuda T, Nakamura Y, Jimi E, Natsume T, and Katagiri T
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Journal Title
J Cell Biochem
Volume: 113
Pages: 808-814
Peer Reviewed
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