2012 Fiscal Year Final Research Report
Effects of Highly-concentrated Inhalational anesthetic exposure during pregnancy on neurodegeneration of neonatal mice
| Project/Area Number |
23659744
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kobe University |
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Principal Investigator |
UOKWA Reiko 神戸大学, 医学研究科, 医学研究員 (50467651)
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| Co-Investigator(Kenkyū-buntansha) |
UEKI Masaaki 神戸大学, 大学院・医学研究科, 医学研究員 (20213332)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 吸入麻酔薬 / 妊娠 / 脳神経変性 |
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| Research Abstract |
Exposure of 2.9% isoflurane on pregnant mice (embryonic day 17) had an influence on learning function, morphological synapse formation (synaptophysin staining) and BDNF mRNA on postnatal day 7. Furthermore, exposure of 2.9% isoflurane on pregnant mice effected brain NKCC/KCC2mRNA ratio.
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