2012 Fiscal Year Final Research Report
The role of bone marrow-derived cells in the development of tumor vessels in renal cell carcinoma
| Project/Area Number |
23659757
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 腫瘍学 |
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| Research Abstract |
It is quite important to understand the nature of tumor vessels in the treatment of renal cell cancer (RCC). In this study, we found that EMMPRIN (extracellular matrixmetalloproteinase inducer), which enhances production of collagenase, have an important role in angiogenesis in RCC. Unfortunately, we were not able to clarify the role of bone marrow-derived endothelial progenitor cells (EPC) in the development of tumor vessels, however, it might be possible that in the microenvironment which is modified by expression of EMMPRIN by RCC, EPC plays some role in angiogenesis.
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