2012 Fiscal Year Final Research Report
Development of novel methods for identifying antibiofilm agents against multidrug-resistant Acinetobacter baumannii
| Project/Area Number |
23659759
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Urology
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| Research Institution | Okayama University |
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Principal Investigator |
KUMON Hiromi 岡山大学, 大学院・医歯薬学総合研究科, 教授 (30144760)
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| Co-Investigator(Kenkyū-buntansha) |
KARIYAMA Reiko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (40112148)
MURAKAMI Keiji 徳島大学, 大学院・ヘルスバイオサイエンス 研究部, 助教 (10335804)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGA Hiroaki 東京大学, 大学院・理学系研究科, 教授 (00361668)
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| Research Collaborator |
TAKATA Tohru 福岡大学, 福岡大学病院, 准教授 (90268996)
KOKEGUCHI Susumu 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (10144776)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 細菌 / 感染症 / アシネトバクター / 多剤耐性菌 / アウトブレイク / バイオフィルム / 抗バイオフィルム剤 / 新規治療法 |
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| Research Abstract |
Acinetobactor baumanniiis an increasingly important nosocomial pathogen that causes a broad array of infections, particularly in hospitalized patients. This study was aimed at establishing new strategies for prevention and therapy of multidrug-resistant A. baumanniibiofilms. By using in vitroa n d in vivomodels, we found possible therapeutic approaches for treating biofilm infections caused by multidrug-resistant A. baumannii. Further studies were needed to establish novel models by using real-time imaging.
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