2013 Fiscal Year Final Research Report
Progestogen prevents hypoxic-ischemic encephalopathy of neonatal rats
Project/Area Number |
23659772
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Obstetrics and gynecology
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Research Institution | Chiba University |
Principal Investigator |
SHOZU Makio 千葉大学, 医学(系)研究科(研究院), 教授 (30226302)
|
Co-Investigator(Renkei-kenkyūsha) |
OMOTO Akiko 千葉大学, 医学部附属病院, 助教 (60375764)
|
Project Period (FY) |
2011 – 2012
|
Keywords | 脳性麻痺 / 黄体ホルモン / ニューロステロイド / ラットモデル |
Outline of Final Research Achievements |
To assess neuroprotective actions of progestogen on neonatal rats, an experiment model, in which hypoxic-ischemic insult was applied during late pregnancy, was administered with progestogen after birth and was evaluated in terms of neurological performance and histological changes. We found that some progestogen improved locomotors function and prevented histological brain damage.
|
Free Research Field |
医歯薬学
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