2012 Fiscal Year Final Research Report
Development of a new therapeutics of gestational diabetes by inhibition of the central action of lipid phosphatase
| Project/Area Number |
23659774
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Toyama |
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Principal Investigator |
SASAOKA Toshiyasu 富山大学, 大学院・医学薬学研究部(薬学), 教授 (00272906)
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| Co-Investigator(Kenkyū-buntansha) |
TSUNEKI Hiroshi 富山大学, 大学院・医学薬学研究部(薬学), 准教授 (20332661)
WADA Tsutomu 富山大学, 大学院・医学薬学研究部(薬学), 助教 (00419334)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 妊娠糖尿病 / インスリン抵抗性 / エストロゲン / リピッドホスファターゼ |
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| Research Abstract |
Gestational diabetes increases with the life style changes including high-fat feeding and late marriage, and appropriate treatment against the diabetes is required. Present study demonstrated that a central action of estrogen, which is importantfor maintenance of the pregnancy, plays crucial roles in the control of insulin action and glucose homeostasis in mice. In addition, a lipid phosphatase SHIP2 in hypothalamusaffected feeding behavior and body weight by specifically controlling the insulin action. Thus, we developed new candidate compounds for SHIP2 inhibitors by means of ligand-based drug design. We found that new SHIP2 inhibitors improved insulin resistance and glucose metabolism in diabetic mice. These results indicate that inhibition of SHIP2 appears to be beneficial for the treatment of gestational diabetes
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[Journal Article] Rational design and synthesis of 4-substituted 2-pyridin-2-ylamides with inhibitory effects on SH2 domain-containing inositol 5'-phosphatase 2 (SHIP2)2013
Author(s)
Ichihara Y, Fujimura R, Tsuneki H, Wada T, Okamoto K, Gouda H, Hirono S, Sugimoto K, Matsuya Y, Sasaoka T, Toyooka N
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Journal Title
Eur J Med Chem.
Volume: 62
Pages: 649-660
Peer Reviewed
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[Presentation] Central and peripheral estrogen differentially ameliorates impaired glucose metabolism in postmenopausal obese mice model2012
Author(s)
Yonezawa R, Wada T, Morita M, Sawakawa K, Ishii Y, Sasahara M, Tsuneki H, Sasaoka T, Saito S.
Organizer
American Diabetes Association (ADA) 72th Scientific Sessions
Place of Presentation
Philadelphia, PA, U.S.A.
Year and Date
20120608-12
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