2013 Fiscal Year Final Research Report
Development of novel detection system of circulating tumor cells with tumor-specific replication adenovirus and its clinical application for predicting the recurrence of ovarian cancer
| Project/Area Number |
23659775
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kanazawa University |
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Principal Investigator |
KYO SATORU 金沢大学, 医学系, 准教授 (50272969)
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| Project Period (FY) |
2011 – 2013
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| Keywords | CTC / gynecological cancer / ovarian cancer / telomerase / adenovirus / GFP |
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| Research Abstract |
We established the novel detection system for circulating tumor cells (CTC) with telomerase-specific replication adenovirus in which GFP cDNA was integrated for GFP fluorescence. Infection of these viruses with 5ml of blood samples from the patients with gynecological cancers successfully identified CTC, while no CTC was detectd in the samples from healthy volunteers. While the number or the presence of CTCs were not significantly correlated with clinicopathological characteristics, they were tightly related to the treatment outcome as well as the overall survival. Thus, the present study clearly found the clinical utility of this novel detection system for CTC.
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[Journal Article] Plasma Membrane proteomics identifies bone marrow stromal antigen 2 as a potential therapeutic target in endometrial cancer2013
Author(s)
Yokoyama T, Enomoto T, Serada S, Morimoto A, Matsuzaki S, Ueda Y, Yoshino K, Fujita M, Kyo S, Iwahori K, Fujimoto M, Kimura T and Naka T
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Journal Title
Int. J. Cancer
Volume: 132
Pages: 472-484
Peer Reviewed
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[Journal Article] Establishment of Immortalized Human Amniotic Mesenchymal Stem Cells2013
Author(s)
Teng Z, Yoshida T, Okabe M, Toda A, Higuchi O, Nogami M, Yoneda N, Zhou K, Kyo S, Kiyono T, Nikaido T
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Journal Title
Cell Transplant
Volume: 22
Pages: 267-278
Peer Reviewed
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[Journal Article] Forkhead transcription factor FOXO1 is a direct target of progestin to inhibit endometrial epithelial cell growth2011
Author(s)
Kyo S, Sakaguchi J, Kiyono T, Shimizu Y, Maida Y, Mizumoto Y, Mori N, Nakamura M, Takakura M, Miyake M, Sakamoto M and Inoue M
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Journal Title
Clin. Cancer Res
Volume: 17
Pages: 525-537
Peer Reviewed
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