2012 Fiscal Year Final Research Report
Develop of ovarian cancer stem cell specific immunotherapy based on DNA microarray analysis
| Project/Area Number |
23659777
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Kyoto University |
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Principal Investigator |
KONISHI Ikuo 京都大学, 医学研究科, 教授 (90192062)
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| Co-Investigator(Kenkyū-buntansha) |
MANDAI Masaki 近畿大学, 産婦人科, 教授 (80283597)
HAMANISHI Jyunzo 京都大学, 医学研究科, 助教 (80378736)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 婦人科腫瘍学 |
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| Research Abstract |
From several human ovarian cancer cell lines Hoechst33342 isolated Side population (SP) and major population (MP) by FACS sorting system. DNA microarray analysis showed some specific genes (stemness gene signature) between SP cells and MP cellls, and we chose immune-related genes from stemness gene signature （ Stem-Immuno-Gene Signature: SIGS). Next we analyzed and scored human ovarian caner tissues by using SIGS with ssGSEA method.As the cases with higher SIGS score were significantly worse prognosis, The analyses shown here may lead to a precise understanding of the local immune status and stemness and provide a tool for the application of immune therapies to treat ovarian cancer patients.
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Research Products
(22 results)
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[Journal Article] PD-L1 on Tumor Cells Is Induced in Ascites and Promotes Peritoneal Dissemination of Ovarian Cancer through CTL Dysfunction.2013
Author(s)
Abiko K, Mandai M, Hamanishi J, Yoshioka Y, Matsumura N, Baba T, Yamaguchi K, Murakami R, Yamamoto A, Kharma B, Kosaka K, Konishi I
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Journal Title
Clin Cancer Res
Volume: 19
Pages: 1363-1374
DOI
Peer Reviewed
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