2013 Fiscal Year Final Research Report
Mechanism of sublingual immunotherapy -experimental approach in murine model-
| Project/Area Number |
23659796
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Shimane University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
MORIKURA Ichiro 島根大学, 医学部, 助教 (00362939)
AOI Noriaki 島根大学, 医学部, 講師 (80452556)
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| Project Period (FY) |
2011 – 2013
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| Keywords | アレルギー性鼻炎 / ｽｷﾞ花粉症 / ｽｷﾞ花粉症治療米 / 舌下免疫療法 / regulatory T cells / ＩｇＥ抗体 |
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| Research Abstract |
To elucidate the mechanism of sublingual immunotherapy for allergic rhinitis, we have successfully constructed murine allergic rhinitis model with ovalbumin or cedar pollen as allergens. In this murine model, we demonstrated that sublingual immunotherapy at an induction phase actually attenuates nasal symptoms such as sneezing and nasal rubbing by downregulating allergen-specific IgE in sera. Moreover, allergen-specific regulatory T cells were induced in the cervical lymph node of mice sublingually immunized and these cells singnificantly produced IL-10
in an antigen-specific fashion.
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Research Products
(34 results)
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[Journal Article] Examination, diagnosis and classification for Japanese allergic rhinitis : Japanese guideline2012
Author(s)
Yuichi Kurono, Kimihiro Okubo, Keiichi Ichimura, Tadao Enomoto, Hideyuki Kawauchi, Keisuke Masuyama, Minoru Goto, Harumi Suzaki, Yoshitaka Okamoto, Hiroshi Takenaka
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Journal Title
Auris, nasus, larynx
Volume: 39(6)
Pages: 553-556
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