2012 Fiscal Year Final Research Report
Establishment of therapeutic assessment in glaucoma neuroprotection using live-imaging of axonal transport in optic nerve
| Project/Area Number |
23659814
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Kumamoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Keywords | 緑内障 / 網膜神経節細胞 / 軸索輸送 |
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| Research Abstract |
In vivo imaging of the mice in which fluorescent proteins areexpressed specifically in neuronal mitochondria was conducted using two-photonmicroscopy. As a glaucoma model, ocular hypertension was induced by laser treatment ofepiscleral veins in mice. In vivo imaging of retinal ganglion cells reveals thedisturbance of mitochondrial axonal transport in the mouse glaucoma model before RGC death,suggesting that the abnormal axonal transport is involved in glaucoma pathology
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[Presentation] The Effect of Monocyte ChemoattractantProtein-1/CC Chemokine Ligand 2 on the Aqueous Humor Outflow Facility2012
Author(s)
Tsuboi N,Inoue T, Fujimoto T, Inoue-Mochita M,Kasaoka N, Kawai M, Shobayashi K,Yoshida A, Tanihara H
Organizer
The Annual Meeting of the Associationfor Research in Vision andOphthalmology
Place of Presentation
FortLauderdale, Florida, USA
Year and Date
20120506-0510
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