2012 Fiscal Year Final Research Report
Clinical and molecular biological investigation of glaucomacaused by prostacyclin receptor abnormality
| Project/Area Number |
23659819
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Itaru 順天堂大学, 医学部, 准教授 (60296663)
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| Project Period (FY) |
2010 – 2012
|
| Keywords | 緑内障 / プロスタサイクリン受容体 / 一塩基多型 |
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| Research Abstract |
We are compiling the clinical data as to family and past history, or various expression of glaucoma linking to the information of genomic DNA. We are investigating transfection by several methods in order to overexpress variant prostacyclin receptor in cultured cells like vascular smooth muscle cells or other cells, as a previous step for making knock-in mouse of variant prostacyclin receptor.
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