2013 Fiscal Year Final Research Report
Development of clinically applicable non-invasive cardiac function monitor for children
Project/Area Number |
23659823
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
Pediatric surgery
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Research Institution | University of Tsukuba |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
MATSUSHITA Shonosuke 筑波技術大学, 保健科学部, 准教授 (70359579)
SAKAKIBARA Yuzuru 筑波大学, 医学医療系, 教授 (60192085)
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Project Period (FY) |
2011 – 2012
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Keywords | 先天性心疾患 / 高周波電位 / 小児開心術 |
Research Abstract |
Basic research on development of clinically applicable non-invasive cardiac function monitor in children was conducted by analyzing changes in high-frequency QRS potentials on electrocardiogram during pediatric cardiac surgery. Changes in high-frequency QRS potentials was measured before and after removal of aortic cross-clamp and return of spontaneous heartbeat in pediatric patients undergoing cardiac surgery. Progressive recovery of high frequency QRS potentials was confirmed after reinstitution of myocardial perfusion and degree of high-frequency QRS potential recovery was correlated with improvement in cardiac function and degree of myocardial injury during surgical procedure. Our findings suggest that measurement of high-frequency QRS potentials on electrocardiogram after pediatric open heart surgery is a useful monitor of cardiac function and may have potentials to become an effective non-invasive cardiac function monitor in postoperative open heart surgical children.
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