2012 Fiscal Year Final Research Report
Development of novel biotherapy using hybrid peptide targeting molecules on malignant melanoma
| Project/Area Number |
23659827
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
ISHIGE Kazunori 筑波大学, 医学医療系, 講師 (20597918)
SHODA Junichi 筑波大学, 医学医療系, 教授 (90241827)
TAKEUCHI Kaoru 筑波大学, 医学医療系, 准教授 (00192162)
KAWAKAMI Koji 京都大学, 医学系研究科, 教授 (70422318)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 悪性黒色腫 / サイトカイン / 受容体 / 標的治療 / バイオ療法 |
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| Research Abstract |
Interleukin-4 receptor (IL-4R) is highly expressed on the surface of various human solid tumors including head and neck squamous cell carcinoma (HNSCC). Recently, we designed a novel IL-4R-lytic hybrid peptide composed of a binding peptide to IL-4R and a cell-lytic peptide. We confirmed the antitumor activity of the IL-4R-lytic hybrid peptide as a novel molecular-targeted therapy in several kinds of cancers. Malignant melanoma is a challenging cancer with poorer survival outcome. In addition, oral cavity cancer is also a challenging cancer in its advanced cases. In this study, we evaluated the antitumor activity of the IL-4R-lytic hybrid peptide as a novel molecular-targeted therapy in malignant melanoma and oral cavity cancers. IL-4R was expressed in oral cavity cancer cell lines, but not in a human normal keratinocyte. IL-4R in oral cavity cancer tissue was higher compared to that in normal epithelial tissue. The results revealed the antitumor activity of the IL-4R-lytic hybrid peptide against oral cavity cancers in a dose-dependent manner using the in vitro and in vivo experiments. However, we did not confirm the antitumor activity against malignant melanoma.
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[Journal Article] Presurgical Orthopedic Treatment Ameliorates Postoperative Nasal Deformity after Cheiloplasty2013
Author(s)
Adachi K, Togashi S, Yanagawa T, Ishibashi N, Goto T, Yamagata K, Onizawa K, Sasaki H, Sasaki K, Bukawa H, Sekido M
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Journal Title
Annals of Plastic Surgery
Peer Reviewed
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[Journal Article] Expression of N-acetylglucosaminyltransferase V in the subserosal layer correlates with postsurgical survival of pathological tumor stage 2 carcinoma of the gallbladder2013
Author(s)
Onuki K,Sugiyama H,Ishige K, Kawamoto T,Ota T,Ariizumi S, Yamato M, Kadota S, Takeuchi K, Ishikawa A, Onodera M, Onizawa K, Yamamoto M,Miyoshi E,Shoda J
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Peer Reviewed
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[Journal Article] Potent in vitro and in vivo antitumor activity of sorafenib against human intrahepatic cholangiocarcinoma cells.2011
Author(s)
Sugiyama H, Onuki K, Ishige K, Baba N, Ueda T, Matsuda S, Takeuchi K, OnoderaM,Nakanuma Y,Yamato M, Yamamoto M, Hyodo I, Shoda J
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Journal Title
J Gastroenterol
Volume: 46
Pages: 779-789
Peer Reviewed
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