2012 Fiscal Year Final Research Report
Analysis of expression of Melanopsin in human skin
| Project/Area Number |
23659833
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Kobe University |
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Principal Investigator |
TERASHI Hiroto 神戸大学, 医学部附属病院, 教授 (80217421)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAKIBARA Shunsuke 神戸大学, 医学研究科, 特定助教 (50444592)
FUJII Miki 神戸大学, 医学研究科, 医学研究員 (80444602)
SAKURAI Sayuri 神戸大学, 医学研究科, 特定助教 (20594534)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 創傷治癒学 / 光応答 |
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| Research Abstract |
The expression of Melanopsin in human skin were detected. The localization of its expression were; keratinocyte, melanocyte in epidermis, fibroblast in dermis. Irradiation of 450nm of LED light cause the up regulation of phosphorylation of ERK and degree of phosphorylation were related to the irradiation time. On the other hand, irradiation of 570nm light cause the down regulation of phosphorylation of ERK.Irradiation of both lights causes the more phosphorylation of ERK.
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