2012 Fiscal Year Final Research Report
Research on cell rejuvenation by pluripotent cells
| Project/Area Number |
23659840
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Plastic surgery
|
|---|
| Research Institution | Research Institute, International Medical Center of Japan |
|---|
Principal Investigator |
OKOCHI Hitoshi 独立行政法人国立国際医療研究センター, 細胞組織再生医学研究部, 部長 (30185235)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 再生医学 |
|---|
| Research Abstract |
As cultured dermal papilla cells (DPC) lose hair-inducing ability, we co-cultured mouse DPC with mouse ES cells or iPS cells. We could not keep hair-inducing ability by these methods. Then we fused DPC with mouse ES cells. While fused cells behaved ES-like cells in ES media, they maintained some DPC specific gene expression in DPC culture media.
|
Research Products
(5 results)
-
[Journal Article] Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.2013
Author(s)
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S
-
Journal Title
Proc Natl Acad Sci USA
Volume: 110(16)
Pages: 6412-7
-
-
-
-
