2012 Fiscal Year Final Research Report
Research on cell rejuvenation by pluripotent cells
| Project/Area Number |
23659840
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Plastic surgery
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| Research Institution | Research Institute, International Medical Center of Japan |
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Principal Investigator |
OKOCHI Hitoshi 独立行政法人国立国際医療研究センター, 細胞組織再生医学研究部, 部長 (30185235)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 再生医学 |
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| Research Abstract |
As cultured dermal papilla cells (DPC) lose hair-inducing ability, we co-cultured mouse DPC with mouse ES cells or iPS cells. We could not keep hair-inducing ability by these methods. Then we fused DPC with mouse ES cells. While fused cells behaved ES-like cells in ES media, they maintained some DPC specific gene expression in DPC culture media.
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[Journal Article] Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles.2013
Author(s)
Hikichi T, Matoba R, Ikeda T, Watanabe A, Yamamoto T, Yoshitake S, Tamura-Nakano M, Kimura T, Kamon M, Shimura M, Kawakami K, Okuda A, Okochi H, Inoue T, Suzuki A, Masui S
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Journal Title
Proc Natl Acad Sci USA
Volume: 110(16)
Pages: 6412-7
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