Exploration of cause of death and acute phase treatment for carbondioxide poisoning

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659842
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Emergency medicine
• Research Institution: University of Tsukuba
• Principal Investigator: MIZUTANI Taro 筑波大学, 医学医療系, 教授 (80181890)
• Co-Investigator(Kenkyū-buntansha): SHIMOJO Nobutake 筑波大学, 医学医療系, 講師 (20462210)
• Project Period (FY): 2011 – 2012
• Keywords: 急性中毒学 / 二酸化炭素中毒 / 急性期治療 / 中毒モデル

Research Abstract

The hazardousness is recognized in CO2 poisoning by real cases and disasters, however the mechanism and the direct cause of CO2 poisoning death are not revaeled. To investigate the cause of death, we established model rats and time-dependently measured hemodynamics, blood gas analysis in rats and theconcentration of CO2 and O2 in the chamber. After the sacrifice, we isolated the tissues and analyzed some molecular biological data. This study is very challenging for us to aim to determine the upper limitation of CO2 concentration in the blood and elucidate the mechanism of CO2 poisoning.