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2012 Fiscal Year Final Research Report

Studies on real-time biomarker of illness severity inthe patients of critical illness and development of the diagnosis machine

Research Project

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Project/Area Number 23659846
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeMulti-year Fund
Research Field Emergency medicine
Research InstitutionThe University of Tokushima

Principal Investigator

KIDO Hiroshi  徳島大学, 疾患酵素学研究センター, 教授 (50144978)

Co-Investigator(Renkei-kenkyūsha) NISHIMURA Masaji  徳島大学, ヘルスバイオサイエンス研究部, 教授 (10172701)
CHIDA Junji  徳島大学, 疾患酵素学研究センター, 助教 (20437651)
Project Period (FY) 2011 – 2012
Keywords集中治療室 / ATP / 乳酸 / 重症度 / リアルタイム・バイオマーカー / 予後判定 / エネルギー代謝 / 代謝障害
Research Abstract

Blood ATP levels and lactate/ATP ratioare sensitive, real-time and easy to measure prognostic biomarkers of mortality at the time ofthe intensive care unit admission.

  • Research Products

    (7 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Blood lactate/ATP ratio, as an alarm index and real-time biomarker in critical illness2013

    • Author(s)
      Junji Chida, Rie Ono, Kazuhiko Yamane, Mineyoshi Hiyoshi, Masaji Nishimura, Mutsuo Onodera, Emiko Nakataki, Koichi Shichijo, Masatomi Matushita and Hiroshi Kido
    • Journal Title

      PLoS One

      Volume: 8(4) Pages: e60561

    • DOI

      Doi:10.1371/journal.pone.0060561

    • Peer Reviewed
  • [Journal Article] An efficient extraction method for quantitation of adenosine triphosphate in mammalian tissues and cells2012

    • Author(s)
      Junji Chida, Kazuhiko Yamane, Tunetomo Takei, and Hiroshi Kido
    • Journal Title

      Anal. Chim. Acta

      Volume: 21(728) Pages: 8-12

    • Peer Reviewed
  • [Journal Article] Upregulation of ectopic ytypsins in the myocardium by influenza A virus infection triggers acute myocarditis2011

    • Author(s)
      Hai-Yan Pan, Hirotugu Yamada, Junji Chida, Siye Wang, Mihiro Yano, Min Yao, Jianhua Zhu, and Hiroshi Kido
    • Journal Title

      Cardiovasc. Res

      Volume: 89(3) Pages: 595-603

    • Peer Reviewed
  • [Remarks]

    • URL

      http://www.ier.tokushima-u.ac.jp

  • [Patent(Industrial Property Rights)] 熱中症2012

    • Inventor(s)
      木戸 博
    • Industrial Property Rights Holder
      応用酵素医学研究所株式会社
    • Industrial Property Number
      特願 2011-147227
    • Filing Date
      2012-07-01
  • [Patent(Industrial Property Rights)] 熱中症に対する発症感受性や発症耐性の判定方法2012

    • Inventor(s)
      木戸 博
    • Industrial Property Rights Holder
      応用酵素医学研究所株式会社
    • Industrial Property Number
      PCT/JP2012/004209
    • Filing Date
      2012-06-28
    • Overseas
  • [Patent(Industrial Property Rights)] 病気の重症度の検査方法2011

    • Inventor(s)
      木戸 博、西村 匡司、千田 淳司
    • Industrial Property Rights Holder
      徳島大学
    • Industrial Property Number
      PCT/JP2011/002979
    • Filing Date
      2011-05-31
    • Overseas

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Published: 2014-09-25  

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