2012 Fiscal Year Final Research Report
Molecular analysis of Tbx1-mediated oral adhesion
| Project/Area Number |
23659853
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FUNATO Noriko 東京医科歯科大学, 医歯学研究支援センター, 講師 (10376767)
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| Project Period (FY) |
2011 – 2012
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| Keywords | T-box型転写因子 / 口蓋裂 / 癒合 |
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| Research Abstract |
T-box transcription factor, Tbx1, is the major candidate gene for 22q11.2 deletion syndrome (DiGeorge/ Velo-cardio-facial syndrome) characterized by facial defects, thymus hypoplasia, cardiovascular anomalies, and cleft palates.In this project, we found that genetic disruption of Tbx1, a major candidate gene for the human congenital disorder 22q11.2 deletion syndrome (Velo-cardio-facial/DiGeorge syndrome), led to abnormal epithelial adhesion between the palate and mandible in mouse, resulting in various forms of cleft palate similar to human conditions. Our findings suggested that Tbx1 regulated the balance between proliferation and differentiation of keratinocytes and was essential for palatal fusion and oral mucosal differentiation.
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