2012 Fiscal Year Final Research Report
Investigation for the bone clock development by bioluminescence and fluorescence imaging on brain and bone
| Project/Area Number |
23659855
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
IIMURA Tadahiro 東京医科歯科大学, 歯と骨のGCOE拠点, 特任准教授 (20282775)
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| Co-Investigator(Renkei-kenkyūsha) |
NUMANO Rika 豊橋技術科学大学, 准教授 (30462716)
YAMAGUCHI Akira 東京医科歯科大学, 大学院, 教授 (00142430)
MIYAWAKI Atsushi 独立行政法人理化学研究所, チームリーダー (80251445)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨 / イメージング / 分子時計 |
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| Research Abstract |
Bone metabolism is regulated by circadian clock. On the other hand, the central clock system in brain is thought to regulate peripheral clocks including bone. We established a dual imaging system of bioluminescence and fluorescence, which enables us to monitor circadian oscillation from body to cell levels. By exploiting this system, inter-regulation between brain and bone well be further investigated.
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[Journal Article] Retention of bone strength by feeding of milk and dairy products in ovariectomized rats: involvement of changes in serum levels of 1alpha, 25(OH)(2)D(3) and FGF23.2013
Author(s)
Tanabe R, Haraikawa M, Sogabe N, Sugimoto A, Kawamura Y, Takasugi S, Nagata M, Nakane A, Yamaguchi A, Iimura T, Goseki-Sone M.
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Journal Title
J Nutr Biochem
Volume: 24(6)
Pages: 1000-7
DOI
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[Journal Article] CXCL2 synthesized by oral squamous cell carcinoma is involved in cancer-associated bone destruction.2012
Author(s)
Oue E, Lee JW, Sakamoto K, Iimura T, Aoki K, Kayamori K, Michi Y, Yamashiro M, Harada K, Amagasa T, Yamaguchi A.
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Journal Title
Biochem Biophys Res Commun
Volume: 424
Pages: 456-61
DOI
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[Journal Article] Cdc42 is required for chondrogenesis and interdigital programmed cell death during limb development.2012
Author(s)
Aizawa R, Yamada A, Suzuki D, Iimura T, Kassai H, Harada T, Tsukasaki M, Yamamoto G, Tachikawa T, Nakao K, Yamamoto M, Yamaguchi A, Aiba A, Kamijo R
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Journal Title
Mech Dev l2012
Volume: 129
Pages: 38-50
DOI
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