The involvement and their molecular mechanism of microRNAs in the invasion of oral cancer

2012 Fiscal Year Final Research Report

• Project/Area Number: 23659858
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Morphological basic dentistry
• Research Institution: The University of Tokushima (2012); Hiroshima University (2011)
• Principal Investigator: KUDO Yasusei 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 准教授 (50314753)
• Project Period (FY): 2011 – 2012
• Keywords: 口腔病理学

Research Abstract

We identified miR-203 as an invasion related microRNA (miRNA) by comparing miRNA expression profile between oral cancer cell line and its highly invasive clone. Moreover, we identified NUAK and SNAI2 as a target mRNA of miR-203.

Research Products

• [Journal Article] Matrix metalloproteinase-13 directly and indirectly promotes tumor angiogenesis (2012)
  • Author(s): Kudo, Y.*, Iizuka, S., Yoshida, M., Tsunematsu, T., Subarnbhesaj, A., Siriwardena, S.B.S.M., Tahara, H., Ogawa, I., Takata, T
  • Journal Title: J Biol Chem Volume: 287 Pages: 38716-38728
  • Peer Reviewed
• [Journal Article] Periostin promotes tumor lymphangiogenesis in a direct and an indirect manner (2012)
  • Author(s): Kudo, Y.*, Iizuka, S., Yoshida, M., Nguyen, P.T., Siriwardena, S.B.S.M., Tsunematsu, T., Obayashi, M., Ando, T., Hatakeyama, D., Shibata, T., Koizumi, K., Maeda, M., Ogawa, I., Takata, T
  • Journal Title: PLoS ONE Volume: 7 Pages: e44488
  • DOI: doi:10.1371/journal.pone.0044488
  • Peer Reviewed
• [Journal Article] The 3D tissue microenvironment modulates DNA methylation and E-cadherin expression in squamous cell carcinoma (2012)
  • Author(s): Desrochers, T.M., Shamis, Y., Alt-Holland, A., Kudo, Y., Takata, T., Wang, G., Jackson-Grusby, L., Garlick, J.A
  • Journal Title: Epigenetics Volume: 7 Pages: 34-46
• [Journal Article] MMP-10/stromelysin-2 promotes invasion of head and neck cancer (2011)
  • Author(s): Deraz, E.M., Kudo, Y.*, Yoshida, M., Tani, H., Tsunematsu, T., Siriwardena, B.S.M.S., Kiekhaee, M.R., Qi, G., Iizuka, S., Ogawa, I., Campisi, G., Lo Muzio, L., Abiko, Y., Kikuchi, A., Takata, T
  • Journal Title: PLoS ONE Volume: 6(10) Pages: e25438
  • DOI: doi:10.1371/journal.pone.0025438
  • Peer Reviewed
• [Journal Article] miR-22 represses cancer progression by inducing celular senescence (2011)
  • Author(s): Xu, D., Takeshita, F., Hino, Y., Fukunaga, S., Kudo, Y., Tamaki, A., Takata, T., Shimamoto, A., Ochiya, T., Tahara, H
  • Journal Title: J Cell Biol Volume: 193(2) Pages: 409-424
  • Peer Reviewed
• [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定 (2012)
  • Author(s): 大林真理子,吉田真希,工藤 保誠, 高田 隆
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌市(ロイトン札幌)
  • Year and Date: 20120919-21
• [Presentation] FGFR-1 inhibitor PD173074 induces mesenchymal-epithelial tramsition through suppression of AP-1 in Head and Neck Squamous Cell Carcinoma (2012)
  • Author(s): Nguyen PT, Inubushi T, Tsunematsu T, Kudo Y, Kamata N, Ogawa I, Takata T
  • Organizer: 第23回日本臨床口腔病理学会・学術大会
  • Place of Presentation: 東京都(東京医科歯科大学)
  • Year and Date: 2012-08-30
• [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定 (2011)
  • Author(s): 大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆
  • Organizer: 第3回 RNAi 研究会
  • Place of Presentation: 広島市(広島プリンスホテル)
  • Year and Date: 20110826-27
• [Presentation] 口腔癌における浸潤抑制因子としてのmiR-203 の同定 (2011)
  • Author(s): 大林真理子,工藤保誠,吉田真希,日野由美子,福永早央里,田原栄俊,高田 隆
  • Organizer: 第30回分子病理学研究会
  • Place of Presentation: 倉敷市(下電ホテル)
  • Year and Date: 20110722-24
• [Presentation] Identification of microRNA-203 as an inhibitor of invasion in oral cancer (2011)
  • Author(s): Obayashi M, Kudo Y, Yoshida M, Hino Y, Fukunaga S, Tahara H, Takata T
  • Organizer: 59thJADR Annual Meeting
  • Place of Presentation: 広島市(広島国際会議場)
  • Year and Date: 2011-08-09