2013 Fiscal Year Final Research Report
Transcription factors required for salivary gland regeneration
| Project/Area Number |
23659864
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Osaka Dental University |
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Principal Investigator |
HIEDA Yohki 大阪歯科大学, 歯学部, 准教授 (30243132)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Takayoshi 大阪大学, 歯学研究科, 教授 (90379082)
MISHIMA Kenji 昭和大学, 歯学部, 教授 (50275343)
SAITO Ichiro 鶴見大学, 歯学部, 教授 (60147634)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 唾液腺 / 転写因子 / 分化 / 再生 |
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| Research Abstract |
We tried to isolate several cell types of the mouse submandibular gland and to identify transcription factor genes expressed by the cell types. FACS analysis demonstrated the classification of salivary gland cells into four types, namely, CD66a(+)CD117(-) cells of acini, CD66a(+)CD117(+) intercalated duct cells, and CD66a(-)CD117(+) and CD66a(-)CD117(-) cells including ductal cells and myoepithelial cells. We have not yet identify transcription factors expressed in these FACS-isolated cells.
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