2012 Fiscal Year Final Research Report
Molecular Regulation of Bone Formation in Jaw
| Project/Area Number |
23659868
|
|---|
| Research Category |
Grant-in-Aid for Challenging Exploratory Research
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Functional basic dentistry
|
|---|
| Research Institution | Tokyo Medical and Dental University |
|---|
Principal Investigator |
NODA Masaki 東京医科歯科大学, 難治疾患研究所, 教授 (50231725)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Keywords | 歯科薬理学 |
|---|
| Research Abstract |
Jaw bone is important for mastification. However, the mechanism underlying the maintenance of jaw bone has not been fully understood. We have examined the role of TRPV4 in the regulation of bone mass especially in jaw bone. In the presence of TRPV4, jaw bone is maintained, while the absence of TRPV4 suppressed the levels of bone mass in jaw bone specifically as it did not change the levels of bone mass in parietal bone. TRPV4 gene expression is enhanced by differentiation of osteoblasts as well as the treatment with BMP2. TRPV4 is activated not only by it’s agonist but also fluid flow as a mechanical stress. These data indicate that jaw bone is regulated by TRPV4 for its maintenance of the bone mass.
|
