2012 Fiscal Year Final Research Report
Identification of genes involved in biological crosstalk between cancer and bone
| Project/Area Number |
23659870
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Functional basic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
HATA Kenji 大阪大学, 歯学研究科, 准教授 (80444496)
TANAKA Soichi 大阪大学, 歯学研究科, 助教 (20548200)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 骨転移 / 乳癌細胞 |
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| Research Abstract |
Crosstalk between cancer cells and bone microenvironments is critical to the development and progression of bone metastases. To determine the molecular basis of bone metastasis, we attempted to uncover the molecules that are expressed in breast cancer cells under the influences of bone microenvironments. We have identified 154 genes by microarray analysis. We found that docking protein NEDD9 that is up-regulated by bone-derived TGF・・is critical to the development of bone metastasis. Further determination of the function of genes identified by this study may lead to design new molecular therapeutic approaches for the treatment of bone metastasis.
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