2012 Fiscal Year Final Research Report
Radiosensitization of oral cancer cells by expressing abnormalHuntingtin
| Project/Area Number |
23659876
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MIURA Masahiko 東京医科歯科大学, 大学院・医歯学総合研究科, 教授 (10272600)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 実験腫瘍学 / 放射線増感 |
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| Research Abstract |
The purpose of this study was to explore the hypothesis that tumor cells should be radiosensitized by expressing the abnormal Hungtingtin protein because the repair of DNA double strand breaks (DSB) is reported to be inhibited in neurons expressing such a protein due to exhaustion of Ku70 essential for the DSB repair. We found that tumor cells forming nuclear inclusion bodies exhibit inhibition of DSB repair and radiosensitization. Efficient expression must be obtained as a radiosensitizing strategy and further study is required.
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