2012 Fiscal Year Final Research Report
Analysis of sexdimorphism of autoimmune disease with gene-manipulated models
| Project/Area Number |
23659879
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
YAMADA Akiko 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (70452646)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 自己免疫疾患 / 性ホルモン / シェーグレン症候群 |
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| Research Abstract |
To understand the relationship between autoimmunity and sex hormones, we analyzed the role of aromatase on the onset of autoimmune disease using ArKO mice. As a result, we showed that CD4+T cells produced IFN-・in ArKO mice. Moreover, the numbers of dendritic cells and macrophages were increased in ArKO mice. This finding suggested that dendritic cells and macrophages may activate CD4+T cells and induce inflammation.
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