2013 Fiscal Year Final Research Report
The mechanisms of bone-selective cancer metastases based on the pre-metastatic bone niche hypothesis
| Project/Area Number |
23659883
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Matsumoto Dental University |
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Principal Investigator |
HIRAGA TORU 松本歯科大学, 歯学部, 准教授 (70322170)
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| Co-Investigator(Kenkyū-buntansha) |
HOSOYA Akihiro 松本歯科大学, 歯学部, 講師 (70350824)
NINOMIYA Tadashi 松本歯科大学, 総合歯科医学研究所, 講師 (00360222)
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| Project Period (FY) |
2011 – 2013
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| Keywords | 癌 / 骨転移 / 前転移ニッチ |
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| Research Abstract |
In the present study, we examined whether the changes in bone marrow cell population in tumor-bearing mice affect the development of bone metastases. Both in the bone marrow in the tumor-bearing mice and in the bone marrow with tumor metastases, the ratio of Gr-1+/CD11b+ cells was markedly increased. Furthermore, the inoculation of tumor cells with Gr-1+/CD11b+ cells isolated from tumor-bearing mice enhanced the formation of subcutaneous tumors. However, bone metastases were not increased in the presence of subcutaneous tumors. Further studies are required to fully define the relationship between bone marrow Gr-1+/CD11b+ cells and the development of bone metastases.
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Author(s)
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Journal Title
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Adv Space Res
Volume: 47(7)
Pages: 1214-24
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