2012 Fiscal Year Final Research Report
Effects of soluble carbodiimide on the strengthening mechanism of human dentin by collagen cross-linking
| Project/Area Number |
23659888
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
HAYASHI Mikako 大阪大学, 歯学研究科(研究院), 教授 (40271027)
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| Co-Investigator(Renkei-kenkyūsha) |
斎藤 充 東京慈恵会医科大学, 医学部, 准教授 (50301528)
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| Project Period (FY) |
2011 – 2012
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| Keywords | 保存修復学 / 象牙質 / 機械的強度 / 水溶性カルボジイミド / コラーゲン |
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| Research Abstract |
The strengthening effects of human dentin by soluble carbodiimide were investigated with an aim of preventing tooth fracture. We found that soluble carbodiimide was significantly effective to improve the mechanical strengths of dentin. The strengthening mechanism of dentin by heating was found to promote new collagen cross-linking with relation to water molecules.
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