2012 Fiscal Year Final Research Report
Dental Pulp treatment using artificial protein with biomeneralization
| Project/Area Number |
23659892
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Conservative dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
INOUE Takashi 東京歯科大学, 歯学部, 教授 (20125008)
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| Co-Investigator(Renkei-kenkyūsha) |
芝 清隆 (40196415)
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| Project Period (FY) |
2011 – 2012
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| Keywords | ペプチドアプタマー / バイオミネラリゼーション / 歯髄 / 石灰化 |
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| Research Abstract |
When the tooth received the obstacle owing to dental caries or externally caused injury, it was difficult to save the dental pulp tissue because of a patient's pain. However, dental-pulp-extraction disposal makes a peri-apical lesion such as radicular cyst in many cases. The purpose of this project was to make a pulp calcify itself. Therefore, the peptide aptamer (peptide specifically combined with a specific molecule) which starts biomineralization combines with the collagen which occupies most components of a pulp chamber, a nerve fiber, and a blood vessel . We tried to urge calcification of the pulp chamber in the living body. We already published the paper in which we develop the aptamer bind either titanium or zirconium, directivity(Biomacromelecules, 9: 3098-3105, 2008, Dental Materials Journal 30: 935-940, 2011).Moreover, also by in vivo, the paper was received by J Biomed. Materials. Res. 2013 . Within study duration, the peptide aptamer combined with collagen, a nerve fiber, and a blood vessel was invented, the aptamer which starts biomineralization was selected, and the function was checked by in vitro. Research is due to consider clinical application to be the selection and to be continued from now on.
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[Journal Article] Chiral meta-molecules consisting of gold nanoparticles and genetically engineered tobacco mosaic virus.2012
Author(s)
Kobayashi, M., Tomita, S., Sawada, K., Shiba, K., Yanagi, H., Yamashita, I., & Uraoka, Y
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Journal Title
Optics express
Volume: 20
Pages: 24856-24863
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[Presentation] 高機能ジルコニアインプラントシステムの開発2012
Author(s)
吉成正雄, 井上 孝, 矢島 安朝, 佐藤亨, 加藤 哲男, 関根 秀志, 松坂 賢一, 三浦 直, 齋藤 健介, 本間 慎也, 佐々木 穂高, 高野 智史, 橋本 和彦, 田辺 耕士, 江川 昌宏, 小山 拓, 渡邊 浩章, 伊藤 寛史, 飯島 俊彦, 小舩 和弘, 金子 創
Organizer
第22回日本歯科医学会総会
Year and Date
20120000
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