2012 Fiscal Year Final Research Report
Development of virus-free generation and xeno-free culture of human gingiva-derived iPS cells
| Project/Area Number |
23659896
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Prosthetic dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
YATANI Hirofumi 大阪大学, 大学院・歯学研究科, 教授 (80174530)
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| Co-Investigator(Kenkyū-buntansha) |
EGUSA Hiroshi 大阪大学, 大学院・歯学研究科, 助教 (30379078)
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| Research Collaborator |
YU Guannan 大阪大学, 大学院・歯学研究科, 大学院生
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| Project Period (FY) |
2011 – 2012
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| Keywords | iPS細胞 / 歯肉 / ウイルスフリー |
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| Research Abstract |
iPS cells are expected to be a powerful tool for regenerative treatments; however, problems that need to be addressed prior to clinical application include viral-vector-derived insertional mutagenesis and the use of animal-derived feeder cells for culture. We generated human gingival fibroblast (hGF)-derived iPS cells with episomal plasmid vectors. The resulting iPS cell clones could be maintained on hGF feeder cells. The virus-free and autologous culture of hGF derived-iPS cells thus represents an important step toward the future therapeutic usage of iPS cells.
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[Remarks] (1) 毎日新聞:夢を現実に 続く挑戦-歯ぐき 捨てずに生かす・iPS 細胞活用(2011年11月8日)
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[Remarks] (1) 江草 宏.国際歯科研究学会(IADR)Distinguished Scientist Award (Young Investigator Award),2012年6月 20日
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[Remarks] (2) 江草 宏.大阪大学功績賞,2011年8月1日
